Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16584845 | 0.82 | LMNA (0.44) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL28412788 | 0.82 | LMNA (0.44) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL14615689 | 0.78 | LMNA (0.56) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL28952330 | 0.78 | LMNA (0.56) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10266100 | 0.76 | CHRNB2 (0.38) | CHRNB2CHRNB4CHRNA4CHRNA3ALDH1A1 | |
| SCHEMBL28520329 | 0.76 | LMNA (0.54) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL28520331 | 0.76 | LMNA (0.54) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL18526466 | 0.76 | LMNA (0.54) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4760619 | 0.74 | LMNA (0.52) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL22799246 | 0.74 | LMNA (0.52) | LMNACHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837250-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD (CN) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020035052-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-02-20 | — | — | WO | disclosed |