Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALPL | P05186 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172385 | 0.80 | KDM4E (0.39) | TP53MAPTALPLKDM4EALDH1A1 | |
| SCHEMBL2171240 | 0.79 | KDM4E (0.39) | TP53MAPTALPLKDM4EALDH1A1 | |
| SCHEMBL2172957 | 0.78 | PIK3CA (0.53) | ALPLKDM4EALDH1A1HSD17B10PIK3CA | |
| SCHEMBL2171308 | 0.78 | PIK3CA (0.53) | TP53MAPTALPLKDM4EALDH1A1 | |
| SCHEMBL2173919 | 0.78 | GPBAR1 (0.44) | TP53MAPTALPLKDM4EALDH1A1 | |
| SCHEMBL2172365 | 0.78 | HCRTR2 (0.40) | ALPLKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2173329 | 0.78 | GPBAR1 (0.47) | TP53MAPTALPLKDM4EALDH1A1 | |
| SCHEMBL2174569 | 0.77 | MAPT (0.60) | TP53MAPTALPLKDM4EALDH1A1 | |
| SCHEMBL2175693 | 0.76 | ALPL (0.41) | TP53MAPTALPLKDM4EALDH1A1 | |
| SCHEMBL2171314 | 0.76 | GPBAR1 (0.47) | TP53MAPTALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | claimed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | claimed |
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |