Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23717786 | 0.93 | CYP1A2 (0.35) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL21725530 | 0.89 | NPC1 (0.33) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL22400168 | 0.76 | PDPK1 (0.34) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL21859720 | 0.69 | ALDH1A1 (0.33) | PDPK1HSD17B10ALDH1A1TSHRHTT | |
| SCHEMBL25541484 | 0.67 | NR1I2 (0.36) | SMN1; SMN2KDM4EHSD17B10ALDH1A1HTT | |
| SCHEMBL19578800 | 0.67 | PPARA (0.41) | IDO1TSHRMEN1KMT2AGLA | |
| SCHEMBL25065157 | 0.67 | HTR2A (0.33) | CYP2C19KDRFLT3 | |
| SCHEMBL20738344 | 0.67 | IDO1 (0.39) | NPC1RAB9AIDO1KDM4EGAA | |
| SCHEMBL20621620 | 0.67 | NR1I2 (0.34) | SMN1; SMN2CYP1A2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL21143476 | 0.67 | NR1I2 (0.34) | SMN1; SMN2CYP1A2KDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10562884-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10562884-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | MC3R, MC1R, MC2R | NPC1 1729/4885RAB9A 2774/4885SMN1; SMN2 2938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.