Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 7/20 | 0.49 |
| ▸ | GNAI3 | P08754 | 6/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.49 |
| ▸ | LSS | P48449 | 2/20 | 0.49 |
| ▸ | GUSB | P08236 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18885285 | 1.00 | GNAO1 (0.49) | GNAO1GNAI3GNAI1LSSGUSB | |
| SCHEMBL19286115 | 1.00 | GNAO1 (0.49) | GNAO1GNAI3GNAI1LSSGUSB | |
| SCHEMBL28740098 | 1.00 | GNAO1 (0.49) | GNAO1GNAI3GNAI1LSSGUSB | |
| SCHEMBL14539276 | 1.00 | GNAO1 (0.49) | GNAO1GNAI3GNAI1LSSGUSB | |
| Bromide SCHEMBL23004186 | 0.98 | GNAO1 (0.47) | GNAO1GNAI3GNAI1LSSGUSB | |
| Iodide SCHEMBL15008877 | 0.98 | GNAO1 (0.47) | GNAO1GNAI3GNAI1LSSGUSB | |
| Iodide SCHEMBL15008387 | 0.98 | GNAO1 (0.47) | GNAO1GNAI3GNAI1LSSGUSB | |
| Iodide SCHEMBL15008979 | 0.98 | GNAO1 (0.47) | GNAO1GNAI3GNAI1LSSGUSB | |
| Iodide SCHEMBL15008671 | 0.98 | GNAO1 (0.47) | GNAO1GNAI3GNAI1LSSGUSB | |
| Hydrochloric Acid SCHEMBL23004465 | 0.98 | GNAO1 (0.51) | GNAO1GNAI3GNAI1LSSGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230135560-A1 | GEM-DISUBSTITUTED PIPERIDINE MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2023-05-04 | — | — | US | disclosed |
| US-10981894-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2021-04-20 | — | — | US | disclosed |
| US-10766877-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10604507-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-03-31 | — | — | US | disclosed |
| US-10562884-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10604507-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | MC3R, MC1R, MC2R | GNAO1 534/4885GNAI3 656/4885GNAI1 664/4885 |
| US-10562884-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | MC3R, MC1R, MC2R | GNAO1 534/4885GNAI3 656/4885GNAI1 664/4885 |
| US-20230135560-A1 | GEM-DISUBSTITUTED PIPERIDINE MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | MC1R, MC3R, MC2R | GNAO1 131/4885GNAI3 88/4885GNAI1 79/4885 |
| US-10766877-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | MC3R, MC1R, MC2R | GNAO1 534/4885GNAI3 656/4885GNAI1 664/4885 |
| US-10981894-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | MC3R, MC1R, MC2R | GNAO1 534/4885GNAI3 656/4885GNAI1 664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.