Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.54 |
| ▸ | CA2 | P00918 | 7/20 | 0.54 |
| ▸ | CA9 | Q16790 | 6/20 | 0.54 |
| ▸ | CA12 | O43570 | 4/20 | 0.54 |
| ▸ | CA4 | P22748 | 2/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18407955 | 0.87 | POLB (0.48) | CA1CA2CA9THRBPOLB | |
| SCHEMBL18407885 | 0.85 | MEN1 (0.50) | CA1CA2CA9CA12THRB | |
| SCHEMBL21727502 | 0.85 | THRB (0.47) | CA1CA2CA9THRBPOLB | |
| SCHEMBL21727607 | 0.84 | CYP1A2 (0.48) | CA1CA2CA9THRBPOLB | |
| SCHEMBL18408005 | 0.84 | CA2 (0.59) | CA2THRBPOLBLMNATDP1 | |
| SCHEMBL21727581 | 0.83 | TP53 (0.48) | CA1CA2CA9THRBPOLB | |
| SCHEMBL18407909 | 0.82 | TP53 (0.57) | CA1CA2CA9CA7THRB | |
| SCHEMBL23715725 | 0.82 | GRM5 (0.44) | CA9CA12THRBPOLBLMNA | |
| SCHEMBL18407921 | 0.81 | GRM4 (0.47) | CA1CA2CA9THRBPOLB | |
| SCHEMBL18407886 | 0.80 | CYP1A2 (0.50) | CA1CA2CA9THRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3121164-B1 | SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2020-02-19 | — | — | EP | disclosed |