Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5668362 | 0.89 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL2174484 | 0.88 | IGF1R (0.49) | SMN1; SMN2KMT2AMEN1IGF1RNPC1 | |
| SCHEMBL2173689 | 0.87 | CNR1 (0.53) | SMN1; SMN2ALDH1A1KMT2AMEN1IGF1R | |
| SCHEMBL5670028 | 0.83 | IGF1R (0.56) | SMN1; SMN2ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL5668546 | 0.80 | IGF1R (0.49) | SMN1; SMN2KMT2AMEN1IGF1RNPC1 | |
| SCHEMBL5668870 | 0.80 | IGF1R (0.51) | SMN1; SMN2ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL2171406 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL10126403 | 0.79 | IGF1R (0.52) | SMN1; SMN2ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL2174354 | 0.79 | HDAC3 (0.52) | SMN1; SMN2ALDH1A1KMT2AMEN1IGF1R | |
| SCHEMBL2172958 | 0.79 | CNR1 (0.54) | SMN1; SMN2ALDH1A1KMT2AMEN1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973061-B2 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2011-07-05 | — | — | US | disclosed |