Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | GABRP | O00591 | 5/20 | 0.59 |
| ▸ | GABRD | O14764 | 5/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.59 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.59 |
| ▸ | GABRE | P78334 | 5/20 | 0.59 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.59 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.59 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.59 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10857780 | 0.89 | STAT3 (0.69) | KDM4EALDH1A1MAPTGABRPGABRD | |
| SCHEMBL29424976 | 0.87 | MAPT (0.71) | KDM4EALDH1A1MAPTGABRPGABRD | |
| SCHEMBL21724980 | 0.87 | MAPT (0.71) | KDM4EALDH1A1MAPTGABRPGABRD | |
| SCHEMBL2216825 | 0.85 | MAPT (0.77) | KDM4EALDH1A1MAPTGABRPGABRD | |
| SCHEMBL28429347 | 0.84 | STAT3 (0.52) | KDM4EALDH1A1MAPTGABRPGABRD | |
| SCHEMBL2217085 | 0.83 | GABRP (0.80) | KDM4EALDH1A1MAPTGABRPGABRD | |
| SCHEMBL29424987 | 0.81 | HDAC3 (0.55) | KDM4EALDH1A1MAPTGABRPGABRD | |
| SCHEMBL2214523 | 0.81 | GABRP (0.66) | KDM4EALDH1A1MAPTGABRPGABRD | |
| SCHEMBL28127417 | 0.81 | MEN1 (0.66) | KDM4EALDH1A1MAPTGABRPGABRD | |
| SCHEMBL29424986 | 0.81 | STAT3 (0.62) | KDM4EALDH1A1MAPTGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037116-A1 | SMALL MOLECULE PYRIN-DOMAIN TARGETED NLRP3 INFLAMMASOME INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2020-02-20 | — | — | WO | disclosed |