Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | EIF2AK1 | Q9BQI3 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171124 | 0.76 | PGR (0.41) | MAPTTP53THRBMEN1LMNA | |
| SCHEMBL2173424 | 0.69 | MAPT (0.46) | KDM4EGAAALDH1A1MAPTMAOB | |
| SCHEMBL2171582 | 0.67 | MAPT (0.46) | KDM4EGAAALDH1A1ROCK2MAPT | |
| SCHEMBL2172075 | 0.66 | KDM4E (0.42) | KDM4EALDH1A1MAPTTP53THRB | |
| SCHEMBL2171158 | 0.64 | TP53 (0.43) | KDM4EALDH1A1MAPTTP53THRB | |
| SCHEMBL2173419 | 0.63 | TP53 (0.44) | MAPTMAOBTP53THRBKMT2A | |
| SCHEMBL10883557 | 0.62 | GAA (0.51) | KDM4EGAAALDH1A1ROCK2GRK2 | |
| SCHEMBL10886957 | 0.62 | KDM4E (0.48) | KDM4EGAAALDH1A1ROCK2GRK2 | |
| SCHEMBL27930724 | 0.61 | MAPT (0.60) | KDM4EGAAALDH1A1MAPTEGFR | |
| SCHEMBL11526578 | 0.60 | MAPT (0.78) | ALDH1A1MAPTMEN1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |