Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 11/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171158 | 0.84 | TP53 (0.43) | KDM4EALDH1A1ALPLHSD17B10MEN1 | |
| SCHEMBL3518121 | 0.84 | ALDH1A1 (0.43) | KDM4EALDH1A1ALPLHSD17B10MEN1 | |
| SCHEMBL2171482 | 0.81 | KDM4E (0.59) | KDM4EALDH1A1ALPLHSD17B10KMT2A | |
| SCHEMBL2175607 | 0.80 | HCAR2 (0.40) | KDM4EALDH1A1ALPLHSD17B10KMT2A | |
| SCHEMBL2171831 | 0.80 | HCAR2 (0.40) | KDM4EALDH1A1ALPLHSD17B10KMT2A | |
| SCHEMBL2171124 | 0.78 | PGR (0.41) | MEN1CYP1A2CYP2C9KMT2ATP53 | |
| SCHEMBL16334566 | 0.78 | HCAR2 (0.40) | KDM4EALDH1A1ALPLHSD17B10CYP1A2 | |
| SCHEMBL4729857 | 0.77 | PRKAB2 (0.47) | KDM4EALDH1A1ALPLHSD17B10MAPT | |
| SCHEMBL6647866 | 0.77 | CA2 (0.43) | KDM4EALDH1A1ALPLHSD17B10 | |
| SCHEMBL3520429 | 0.77 | HCAR2 (0.41) | KDM4EALDH1A1ALPLHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |