Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228846 | 0.84 | NFE2L2 (0.42) | KDM4ENFE2L2MEN1MAPTHTT | |
| SCHEMBL26025119 | 0.79 | TDP1 (0.35) | KDM4EMAPTHTTKMT2AFFAR1 | |
| SCHEMBL13083870 | 0.78 | CA12 (0.56) | NFE2L2MEN1MAPTHTTKMT2A | |
| SCHEMBL16437067 | 0.74 | FFAR1 (0.46) | KDM4ENFE2L2MEN1MAPTKMT2A | |
| SCHEMBL12268833 | 0.74 | NFE2L2 (0.44) | KDM4ENFE2L2MEN1MAPTKMT2A | |
| SCHEMBL12662425 | 0.74 | CA1 (0.55) | KDM4ENFE2L2MAPTHTTKMT2A | |
| SCHEMBL18472613 | 0.73 | NFE2L2 (0.61) | KDM4ENFE2L2FFAR1FFAR4CA1 | |
| SCHEMBL166380 | 0.73 | NFE2L2 (0.61) | KDM4ENFE2L2FFAR1FFAR4CA1 | |
| SCHEMBL1331704 | 0.72 | MAOB (0.61) | MEN1HTTKMT2ACA1CA2 | |
| SCHEMBL23875055 | 0.72 | TP53 (0.42) | KDM4ENFE2L2MAPTKMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3611174-B1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | MEDSHINE DISCOVERY INC (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3611174-A1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | Medshine Discovery Inc. (CN) | 2020-02-19 | — | — | EP | disclosed |