Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 14/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.65 |
| ▸ | MMP2 | P08253 | 12/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18043763 | 1.00 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2422925 | 0.95 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL6024779 | 0.95 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2174203 | 0.95 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2173514 | 0.88 | ADAM10 (0.67) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL13015347 | 0.85 | RAB9A (0.52) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2176195 | 0.84 | ADAM10 (0.73) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL3457144 | 0.83 | ADAM10 (0.65) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2173968 | 0.82 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL6336101 | 0.82 | ADAM10 (0.67) | ADAM10ERBB2MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853243-B2 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORPORATION (US) | 2014-10-07 | — | — | US | disclosed |
| US-7973041-B2 | Antiarthritic agents; psoriasis; anticancer agents;antiallergens; metalloprotease inhibitors. | INCYTE CORPORATION (US) | 2011-07-05 | — | — | US | disclosed |
| US-7491724-B2 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORPORATION (US) | 2009-02-17 | — | — | US | disclosed |