Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 12/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21731271 | 0.91 | ADORA2A (0.57) | ADORA2AADORA2BADORA1 | |
| SCHEMBL21731214 | 0.85 | ADORA2A (0.58) | ADORA2AADORA2BADORA1MEN1KMT2A | |
| SCHEMBL21731080 | 0.85 | ADORA2A (0.52) | ADORA2AADORA2BADORA1MEN1KMT2A | |
| SCHEMBL21731079 | 0.84 | ADORA2A (0.57) | ADORA2AADORA2BADORA1MEN1KMT2A | |
| SCHEMBL21731058 | 0.84 | ADORA2A (0.56) | ADORA2AADORA2BADORA1MEN1KMT2A | |
| SCHEMBL21731024 | 0.83 | ADORA2A (0.56) | ADORA2AADORA2BADORA1MEN1KMT2A | |
| SCHEMBL21731025 | 0.81 | ADORA2A (0.54) | ADORA2AADORA2BADORA1MEN1KMT2A | |
| SCHEMBL21731213 | 0.81 | ADORA2A (0.63) | ADORA2AADORA2BADORA1MEN1KMT2A | |
| SCHEMBL21731081 | 0.76 | ADORA2A (0.57) | ADORA2AADORA2BADORA1MEN1KMT2A | |
| SCHEMBL21731143 | 0.76 | ADORA2A (0.58) | ADORA2AADORA2BADORA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3611174-B1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | MEDSHINE DISCOVERY INC (CN) | 2022-06-08 | — | — | EP | disclosed |
| US-11117899-B2 | [1,2,4]triazolo[1,5-c]pyrimidine derivative as A2A receptor inhibitor | MEDSHINE DISCOVERY INC. (CN) | 2021-09-14 | — | — | US | disclosed |
| US-11066411-B2 | — | — | 2021-07-20 | — | — | US | disclosed |
| US-20200131184-A1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | MEDSHINE DISCOVERY INC. (CN) | 2020-04-30 | — | — | US | disclosed |
| EP-3611174-A1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | Medshine Discovery Inc. (CN) | 2020-02-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117899-B2 | [1,2,4]triazolo[1,5-c]pyrimidine derivative as A2A receptor inhibitor | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA2B 4/4885ADORA1 2/4885 |
| US-11066411-B2 | — | ADORA2A, ADORA1, ADORA2B | ADORA2A 1/4885ADORA2B 3/4885ADORA1 2/4885 |
| US-20200131184-A1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA2B 4/4885ADORA1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.