Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 18/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.41 |
| ▸ | IL17A | Q16552 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21732120 | 0.93 | RORC (0.43) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732119 | 0.91 | NTRK1 (0.41) | — | |
| SCHEMBL21732214 | 0.90 | RORC (0.36) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732208 | 0.89 | RORC (0.39) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732266 | 0.88 | RORC (0.38) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732188 | 0.88 | RORC (0.38) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732206 | 0.86 | RORC (0.37) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732254 | 0.84 | NTRK1 (0.41) | — | |
| SCHEMBL21732221 | 0.83 | RORC (0.42) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732220 | 0.82 | NTRK1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |