Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 14/20 | 0.43 |
| ▸ | GBA1 | P04062 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23156744 | 0.84 | KRAS (0.43) | KRAS | |
| SCHEMBL21733918 | 0.83 | GBA1 (0.40) | KRASGBA1SMN1; SMN2LMNATSHR | |
| SCHEMBL21733862 | 0.82 | KRAS (0.41) | KRAS | |
| SCHEMBL21734104 | 0.81 | GBA1 (0.44) | GBA1SMN1; SMN2LMNATSHRNR4A1 | |
| SCHEMBL23156770 | 0.81 | KRAS (0.44) | KRAS | |
| SCHEMBL30178152 | 0.79 | KRAS (0.68) | KRAS | |
| SCHEMBL21733988 | 0.79 | KRAS (0.68) | KRAS | |
| SCHEMBL21722172 | 0.79 | KRAS (0.68) | KRAS | |
| SCHEMBL23979934 | 0.79 | KRAS (0.49) | KRAS | |
| SCHEMBL23979636 | 0.79 | KRAS (0.63) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035031-A1 | FUSED RING COMPOUNDS | GENENTECH, INC. (US) | 2020-02-20 | — | — | WO | disclosed |