Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 16/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TET3 | O43151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.34 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.34 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23156770 | 0.89 | KRAS (0.44) | KRASBTKMAPK1TET3KMT2A | |
| SCHEMBL21733675 | 0.84 | KRAS (0.43) | KRAS | |
| SCHEMBL23156897 | 0.80 | NPSR1 (0.37) | KRASBTKMAPK1KMT2A | |
| SCHEMBL23156905 | 0.78 | KRAS (0.43) | KRASKMT2A | |
| SCHEMBL25021099 | 0.78 | KRAS (0.55) | KRAS | |
| SCHEMBL23156887 | 0.78 | KRAS (0.42) | KRAS | |
| SCHEMBL23156893 | 0.78 | KRAS (0.51) | KRAS | |
| SCHEMBL23156894 | 0.77 | KRAS (0.37) | KRAS | |
| SCHEMBL21733862 | 0.77 | KRAS (0.41) | KRASTET3KMT2AFBXL19CXXC5 | |
| SCHEMBL25020030 | 0.77 | KRAS (0.56) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021058018-A1 | INHIBITORS OF KRAS G12C | BEIGENE, LTD. (KY) | 2021-04-01 | — | — | WO | disclosed |