Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 18/20 | 0.41 |
| ▸ | TET3 | O43151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.34 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.34 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.34 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23385726 | 0.86 | KRAS (0.51) | KRASTET3KMT2AFBXL19CXXC5 | |
| SCHEMBL21733533 | 0.84 | TLR9 (0.38) | — | |
| SCHEMBL21733675 | 0.82 | KRAS (0.43) | KRAS | |
| SCHEMBL21733983 | 0.82 | KRAS (0.62) | KRAS | |
| SCHEMBL30177964 | 0.82 | KRAS (0.62) | KRAS | |
| SCHEMBL21722151 | 0.82 | KRAS (0.62) | KRAS | |
| SCHEMBL21733534 | 0.79 | HTR2C (0.39) | KMT2A | |
| SCHEMBL23385660 | 0.78 | KRAS (0.43) | KRASTET3KMT2AFBXL19CXXC5 | |
| SCHEMBL23645190 | 0.78 | KRAS (0.41) | KRASTET3KMT2AFBXL19CXXC5 | |
| SCHEMBL23156744 | 0.77 | KRAS (0.43) | KRASTET3KMT2AFBXL19CXXC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035031-A1 | FUSED RING COMPOUNDS | GENENTECH, INC. (US) | 2020-02-20 | — | — | WO | disclosed |