Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21734010 | 0.77 | KRAS (0.37) | KMT2AMEN1LMNAALDH1A1NPSR1 | |
| SCHEMBL21722186 | 0.75 | HPRT1 (0.33) | — | |
| SCHEMBL21722277 | 0.73 | KRAS (0.51) | — | |
| SCHEMBL21733743 | 0.73 | KRAS (0.51) | — | |
| SCHEMBL21733396 | 0.73 | KRAS (0.51) | — | |
| SCHEMBL31483708 | 0.73 | GRM7 (0.46) | KMT2AMEN1PARP1HPGD | |
| SCHEMBL20836477 | 0.73 | GRM7 (0.46) | KMT2AMEN1PARP1HPGD | |
| SCHEMBL21722189 | 0.72 | GRM7 (0.32) | — | |
| SCHEMBL30834503 | 0.72 | GRM7 (0.32) | — | |
| SCHEMBL21733506 | 0.71 | MEN1 (0.39) | KMT2AMEN1HPGDLMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035031-A1 | FUSED RING COMPOUNDS | GENENTECH, INC. (US) | 2020-02-20 | — | — | WO | disclosed |