Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21725122 | 0.78 | ALDH1A1 (0.57) | GAAALDH1A1HSD17B10MAPK1HRH3 | |
| SCHEMBL21737951 | 0.77 | ALDH1A1 (0.61) | GAAALDH1A1HSD17B10MAPK1HRH3 | |
| SCHEMBL21725030 | 0.67 | CYP11B1 (0.39) | GAAALDH1A1HSD17B10MAPK1HRH3 | |
| SCHEMBL12744157 | 0.67 | NPC1 (0.41) | ALDH1A1HSD17B10 | |
| SCHEMBL12824322 | 0.66 | ALDH1A1 (0.67) | GAAALDH1A1 | |
| SCHEMBL12744156 | 0.65 | ALDH1A1 (0.36) | GAAALDH1A1 | |
| SCHEMBL21738053 | 0.65 | HRH3 (0.33) | HRH3 | |
| SCHEMBL21738062 | 0.63 | HRH3 (0.35) | ALDH1A1HRH3 | |
| SCHEMBL21738064 | 0.63 | HRH3 (0.35) | ALDH1A1HRH3 | |
| SCHEMBL21738073 | 0.63 | GAA (0.36) | GAAALDH1A1HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020036986-A1 | THIADIAZOLE IRAK4 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2020-02-20 | — | — | WO | disclosed |