Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | PRF1 | P14222 | 3/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21610984 | 0.93 | LRRK2 (0.46) | LRRK2PRF1DDB1CRBNKMT2A | |
| SCHEMBL25453057 | 0.85 | DDB1 (0.40) | LRRK2PRF1DDB1CRBNKMT2A | |
| SCHEMBL26767584 | 0.81 | ESR1 (0.40) | LRRK2PRF1CRBNGABRA1GABRG2 | |
| SCHEMBL21738235 | 0.81 | LRRK2 (0.42) | LRRK2PRF1DDB1CRBNKMT2A | |
| SCHEMBL21954898 | 0.78 | LRRK2 (0.41) | LRRK2PRF1DDB1CRBNKMT2A | |
| SCHEMBL17339035 | 0.78 | MEN1 (0.54) | LRRK2KMT2AMEN1GABRA1GABRG2 | |
| SCHEMBL14993043 | 0.77 | LRRK2 (0.45) | LRRK2PRF1DDB1CRBNKMT2A | |
| SCHEMBL27308798 | 0.76 | ALDH1A1 (0.39) | LRRK2DDB1CRBNKMT2AMEN1 | |
| SCHEMBL23805755 | 0.76 | LRRK2 (0.44) | LRRK2DDB1CRBNKMT2AMEN1 | |
| SCHEMBL21610992 | 0.76 | MEN1 (0.55) | LRRK2PRF1KMT2AMEN1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4265608-A1 | BENZOHETEROCYCLE SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND | Shanghai Jemincare Pharmaceuticals Co., Ltd. (CN) | 2023-10-25 | — | — | EP | disclosed |
| WO-2020036437-A1 | SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT | 재단법인 대구경북첨단의료산업진흥재단 | 2020-02-20 | — | — | WO | disclosed |