Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.45 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22924119 | 0.94 | CYP2D6 (0.45) | HRH3GNAI3GNAO1GNAI1CYP2D6 | |
| SCHEMBL23682741 | 0.89 | CYP2D6 (0.46) | HRH3GNAI3GNAO1GNAI1CYP2D6 | |
| SCHEMBL6941686 | 0.86 | GNAI3 (0.59) | HRH3GNAI3GNAO1GNAI1CYP2D6 | |
| SCHEMBL11569854 | 0.85 | — | — | |
| SCHEMBL29322718 | 0.85 | MAPK1 (0.40) | HRH3GNAI3GNAO1GNAI1CYP2D6 | |
| SCHEMBL21933658 | 0.84 | SIGMAR1 (0.53) | HRH3HRH1SIGMAR1ALDH1A1 | |
| SCHEMBL17623238 | 0.84 | CYP2D6 (0.38) | HRH3CYP2D6CYP2C19SLC6A4SIGMAR1 | |
| SCHEMBL10961176 | 0.83 | CYP2D6 (0.41) | HRH3GNAI3GNAO1GNAI1CYP2D6 | |
| SCHEMBL21738355 | 0.82 | HRH3 (0.46) | HRH3CYP2D6CYP2C19HRH1ALDH1A1 | |
| SCHEMBL19322293 | 0.82 | CYP2D6 (0.50) | HRH3GNAI3GNAO1GNAI1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059834-B2 | Macrocyclic immunomodulators | CHEMOCENTRYX, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200055869-A1 | MACROCYCLIC IMMUNOMODULATORS | CHEMOCENTRYX, INC. | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11059834-B2 | Macrocyclic immunomodulators | IL2, IL2RA, C3AR1 | HRH3 162/4885GNAI3 1417/4885GNAO1 2521/4885 |
| US-20200055869-A1 | MACROCYCLIC IMMUNOMODULATORS | IL2, IL2RA, C3AR1 | HRH3 162/4885GNAI3 1417/4885GNAO1 2521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.