Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16084898 | 0.87 | SLC6A2 (0.40) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 | |
| SCHEMBL19984325 | 0.81 | SLC6A2 (0.39) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 | |
| SCHEMBL18603188 | 0.81 | SLC6A2 (0.39) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 | |
| SCHEMBL19140629 | 0.80 | SLC6A2 (0.38) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 | |
| SCHEMBL16002889 | 0.78 | SLC6A3 (0.43) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 | |
| SCHEMBL19214891 | 0.76 | SLC6A2 (0.38) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 | |
| SCHEMBL18636881 | 0.76 | SLC6A3 (0.39) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 | |
| SCHEMBL7918055 | 0.74 | SLC6A3 (0.39) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 | |
| SCHEMBL6437481 | 0.73 | SHBG (0.46) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 | |
| SCHEMBL16287560 | 0.73 | SHBG (0.44) | SLC6A2SLC6A3SLC6A4CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10870661-B2 | Nitrogen-containing tricyclic derivatives having HIV replication inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2020-12-22 | — | — | US | disclosed |
| US-20200055873-A1 | NITROGEN-CONTAINING TRICYCLIC DERIVATIVES HAVING HIV REPLICATION INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055873-A1 | NITROGEN-CONTAINING TRICYCLIC DERIVATIVES HAVING HIV REPLICATION INHIBITORY ACTIVITY | NR4A3, CCR3, NCOA3 | SLC6A2 1387/4885SLC6A3 400/4885SLC6A4 1326/4885 |
| US-10870661-B2 | Nitrogen-containing tricyclic derivatives having HIV replication inhibitory activity | NR4A3, CCR3, NCOA3 | SLC6A2 1387/4885SLC6A3 400/4885SLC6A4 1326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.