Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 12/20 | 0.40 |
| ▸ | PDCD1LG2 | Q9BQ51 | 9/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22256990 | 0.89 | PDCD1LG2 (0.42) | CYP11B1CYP11B2CD274PDCD1LG2LTA4H | |
| SCHEMBL21673277 | 0.85 | PDCD1LG2 (0.38) | CYP11B1CYP11B2CD274PDCD1LG2KDM4E | |
| SCHEMBL21673296 | 0.83 | CYP11B1 (0.44) | CYP11B1CYP11B2CD274PDCD1LG2LTA4H | |
| SCHEMBL21290758 | 0.81 | CYP2D6 (0.41) | CYP11B1CYP11B2CD274PDCD1LG2LTA4H | |
| SCHEMBL12658986 | 0.79 | NEK2 (0.48) | CYP11B1CYP11B2CD274PDCD1LG2KDM4E | |
| SCHEMBL22053044 | 0.76 | KDM4E (0.36) | CD274PDCD1LG2KDM4EGAAOPRM1 | |
| SCHEMBL21322405 | 0.75 | LTA4H (0.41) | CYP11B1CYP11B2CD274PDCD1LG2LTA4H | |
| SCHEMBL22783791 | 0.74 | CYP11B1 (0.43) | CYP11B1CYP11B2CD274PDCD1LG2LTA4H | |
| SCHEMBL18806108 | 0.74 | CYP11B1 (0.43) | CYP11B1CYP11B2CD274PDCD1LG2LTA4H | |
| SCHEMBL21452277 | 0.74 | CYP11B1 (0.43) | CYP11B1CYP11B2CD274PDCD1LG2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261243-A1 | COMBINATION THERAPIES WITH SETD2 INHIBITORS | Epizyme, Inc. (US) | 2022-12-15 | — | — | WO | disclosed |
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |