Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1LG2 | Q9BQ51 | 7/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21739459 | 0.89 | CYP11B1 (0.47) | PDCD1LG2CD274CYP11B1CYP11B2KDM4E | |
| SCHEMBL21673277 | 0.82 | PDCD1LG2 (0.38) | PDCD1LG2CD274CYP11B1CYP11B2KDM4E | |
| SCHEMBL16751004 | 0.80 | NEK2 (0.46) | PDCD1LG2CD274CYP11B1CYP11B2KMT2A | |
| SCHEMBL25270633 | 0.77 | — | — | |
| SCHEMBL20312857 | 0.76 | CYP11B1 (0.36) | PDCD1LG2CD274CYP11B1CYP11B2KMT2A | |
| SCHEMBL16750019 | 0.76 | CYP11B1 (0.36) | PDCD1LG2CD274CYP11B1CYP11B2KMT2A | |
| SCHEMBL9302395 | 0.75 | CRBN (0.43) | PDCD1LG2CD274CYP11B1CYP11B2KMT2A | |
| SCHEMBL31599526 | 0.75 | CRBN (0.43) | PDCD1LG2CD274CYP11B1CYP11B2KMT2A | |
| SCHEMBL22053044 | 0.73 | KDM4E (0.36) | PDCD1LG2CD274KDM4EOPRM1OPRD1 | |
| SCHEMBL21673296 | 0.73 | CYP11B1 (0.44) | PDCD1LG2CD274CYP11B1CYP11B2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200230117-A1 | NOVEL SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN-2,3-DIOXYGENASE | IOMET PHARMA LTD. (GB) | 2020-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200230117-A1 | NOVEL SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN-2,3-DIOXYGENASE | IDO1, IDO2, TDO2 | PDCD1LG2 2563/4885CD274 2968/4885CYP11B1 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.