Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21740209 | 0.89 | SMYD3 (0.39) | SMYD3DRD2HTR2ADRD3EPHX1 | |
| SCHEMBL21739907 | 0.86 | SMYD3 (0.42) | SMYD3EPHX1RAB9AKMT2AEPHX2 | |
| SCHEMBL21740213 | 0.86 | MTNR1A (0.44) | SMYD3DRD2EPHX1RAB9AKMT2A | |
| SCHEMBL21739921 | 0.84 | EPHX1 (0.49) | EPHX1RAB9AKMT2AEPHX2NPC1 | |
| SCHEMBL21739422 | 0.84 | PTGES (0.42) | SMYD3PTGESDRD2EPHX1KMT2A | |
| SCHEMBL21739169 | 0.83 | POLB (0.41) | SMYD3HTR2AEPHX1RAB9AKMT2A | |
| SCHEMBL25040289 | 0.82 | SSTR4 (0.42) | SMYD3RAB9AKMT2AEPHX2ALDH1A1 | |
| SCHEMBL21739908 | 0.82 | SMYD3 (0.39) | SMYD3PTGESEPHX1RAB9AKMT2A | |
| SCHEMBL21740347 | 0.81 | SMYD3 (0.50) | SMYD3 | |
| SCHEMBL22052079 | 0.80 | KMT2A (0.42) | SMYD3EPHX1RAB9AKMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020112872-A1 | METHODS OF TREATING WHSC1-OVEREXPRESSING CANCERS BY INHIBITING SETD2 | Epizyme, Inc. (US) | 2020-06-04 | — | — | WO | disclosed |
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |