Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | SETD2 | Q9BYW2 | 7/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21886096 | 0.86 | HRH4 (0.40) | GAAMAPTALDH1A1POLBRXFP1 | |
| SCHEMBL22408523 | 0.85 | KDM4E (0.41) | GAAMAPTALDH1A1POLBRXFP1 | |
| SCHEMBL50614 | 0.84 | ALDH1A1 (0.53) | GAAMAPTALDH1A1POLBRXFP1 | |
| SCHEMBL22408352 | 0.79 | ADRA2A (0.39) | GAAMAPTALDH1A1POLBRXFP1 | |
| SCHEMBL25134297 | 0.78 | GAA (0.36) | GAAMAPTALDH1A1POLBRXFP1 | |
| SCHEMBL25134421 | 0.77 | GAA (0.40) | GAAMAPTALDH1A1POLBRXFP1 | |
| SCHEMBL25134479 | 0.76 | ALDH1A1 (0.33) | GAAMAPTALDH1A1POLBRXFP1 | |
| SCHEMBL22408291 | 0.76 | KDM4E (0.44) | GAAMAPTALDH1A1POLBKDM4E | |
| SCHEMBL22052047 | 0.75 | HRH4 (0.43) | KDM4EHRH4SETD2NSD2PDE7A | |
| SCHEMBL25134420 | 0.75 | ALDH1A1 (0.32) | GAAMAPTALDH1A1POLBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |