Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC2 | O75106 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10130720 | 0.82 | AOC2 (0.37) | AOC2PIK3CDALDH1A1GAATHRB | |
| SCHEMBL22387991 | 0.81 | PIK3CD (0.53) | AOC2PIK3CDALDH1A1GAATHRB | |
| SCHEMBL24300045 | 0.79 | AOC2 (0.36) | AOC2PIK3CDL3MBTL1VCPDAO | |
| SCHEMBL29344874 | 0.78 | AOC2 (0.37) | AOC2PIK3CDVCPDAOKCNH2 | |
| SCHEMBL21124357 | 0.77 | AOC2 (0.34) | AOC2PIK3CDVCP | |
| SCHEMBL10250897 | 0.77 | LMNA (0.39) | AOC2ALDH1A1KCNH2HRH3 | |
| SCHEMBL10250697 | 0.75 | TSHR (0.50) | AOC2PIK3CDKCNH2HRH3 | |
| SCHEMBL23108919 | 0.75 | KDM4E (0.34) | AOC2PIK3CDALDH1A1VCPDAO | |
| SCHEMBL10250701 | 0.75 | AOC2 (0.46) | AOC2PIK3CDGAA | |
| SCHEMBL23060215 | 0.74 | AOC2 (0.35) | AOC2PIK3CDVCPDAOKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020112872-A1 | METHODS OF TREATING WHSC1-OVEREXPRESSING CANCERS BY INHIBITING SETD2 | Epizyme, Inc. (US) | 2020-06-04 | — | — | WO | disclosed |
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |