Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15684106 | 0.82 | ALDH1A1 (0.54) | ALDH1A1MAPK1L3MBTL1LMNAADRB2 | |
| SCHEMBL20326171 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL24448626 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL3737614 | 0.79 | HTT (0.54) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL3504292 | 0.79 | NAAA (0.44) | ALDH1A1ADRB2ADRB1ADRB3KMT2A | |
| SCHEMBL18826684 | 0.78 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1LMNAKMT2A | |
| SCHEMBL22481266 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1LMNAADRB2 | |
| SCHEMBL12990128 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1LMNAADRB2 | |
| SCHEMBL12933289 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPK1L3MBTL1LMNAADRB2 | |
| SCHEMBL20943404 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MAPK1L3MBTL1LMNAADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200055845-A1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | AMGEN INC. | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055845-A1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | KRAS, NRAS, HRAS | ALDH1A1 4155/4885MAPK1 682/4885L3MBTL1 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.