Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9279277 | 0.98 | SIGMAR1 (0.54) | SIGMAR1TAAR1HRH3CYP2C19KCNH2 | |
| SCHEMBL10469619 | 0.89 | HRH3 (0.55) | SIGMAR1TAAR1HRH3MEN1KMT2A | |
| SCHEMBL9277454 | 0.88 | SIGMAR1 (0.58) | SIGMAR1TAAR1HRH3CYP2C19KCNH2 | |
| SCHEMBL9279775 | 0.87 | HRH3 (0.54) | SIGMAR1TAAR1HRH3KCNH2MEN1 | |
| SCHEMBL3076824 | 0.86 | CYP2C19 (0.65) | SIGMAR1CYP2C19KMT2AHTTMAPT | |
| SCHEMBL5232155 | 0.85 | SIGMAR1 (0.57) | SIGMAR1TAAR1HRH3CYP2C19HTT | |
| SCHEMBL5253198 | 0.81 | CYP2C19 (0.63) | SIGMAR1CYP2C19KMT2AHTTMAPT | |
| SCHEMBL9378269 | 0.80 | SIGMAR1 (0.51) | SIGMAR1TAAR1HRH3CYP2C19HTT | |
| SCHEMBL5234241 | 0.80 | ALDH1A1 (0.55) | SIGMAR1LMNAALDH1A1 | |
| SCHEMBL29289301 | 0.78 | SIGMAR1 (0.49) | SIGMAR1TAAR1HRH3CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838900-A1 | 3-ARYLOXY-3-ARYL-PROPYLAMINE COMPOUND AND USES THEREOF | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd (CN) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020035070-A1 | 3-ARYLOXY-3-ARYL-PROPYLAMINE COMPOUND AND USES THEREOF | 漳州片仔癀药业股份有限公司 | 2020-02-20 | — | — | WO | disclosed |