Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174360 | 1.00 | MAPT (0.50) | MAPTALDH1A1POLBMAPK1TDP1 | |
| SCHEMBL2190432 | 0.87 | BRD4 (0.45) | MAPTALDH1A1POLBMAPK1TDP1 | |
| SCHEMBL16087500 | 0.83 | MAPT (0.46) | MAPTALDH1A1POLBMAPK1TDP1 | |
| SCHEMBL16087499 | 0.83 | MAPT (0.46) | MAPTALDH1A1POLBMAPK1TDP1 | |
| SCHEMBL14321281 | 0.80 | ALDH1A1 (0.46) | MAPTALDH1A1POLBMAPK1TDP1 | |
| SCHEMBL14321285 | 0.80 | ALDH1A1 (0.46) | MAPTALDH1A1POLBMAPK1TDP1 | |
| SCHEMBL27226322 | 0.80 | MAPT (0.43) | MAPTALDH1A1POLBMAPK1TDP1 | |
| SCHEMBL30802492 | 0.79 | MAPT (0.56) | MAPTPOLBMAPK1TDP1HTT | |
| SCHEMBL16087501 | 0.79 | MAPT (0.45) | MAPTALDH1A1POLBMAPK1TDP1 | |
| SCHEMBL27226688 | 0.76 | MAPT (0.44) | MAPTALDH1A1POLBMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |