Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21744557 | 0.86 | EGLN1 (0.44) | EGLN1ALDH1A1 | |
| SCHEMBL30250133 | 0.81 | EGLN1 (0.46) | EGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL28414160 | 0.81 | EGLN1 (0.46) | EGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL24921531 | 0.80 | EGLN1 (0.50) | EGLN1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL22534381 | 0.76 | RAB9A (0.49) | EGLN1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL31435187 | 0.73 | EGLN1 (0.48) | EGLN1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL28435954 | 0.72 | HDAC4 (0.40) | EGLN1MAPTALDH1A1KDM4E | |
| SCHEMBL28441796 | 0.72 | EGLN1 (0.44) | EGLN1 | |
| SCHEMBL28434522 | 0.72 | KMT2A (0.41) | EGLN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL30451998 | 0.72 | HDAC4 (0.40) | EGLN1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035065-A1 | PYRAZOLE DERIVATIVE AS RET INHIBITOR | 南京明德新药研发有限公司 | 2020-02-20 | — | — | WO | disclosed |