Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380687 | 0.88 | LMNA (0.56) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL14910892 | 0.85 | POLB (0.44) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL15351298 | 0.84 | LMNA (0.48) | LMNAKMT2AKDM4EALDH1A1TP53 | |
| SCHEMBL13822152 | 0.77 | MAPT (0.37) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL29903403 | 0.77 | MAPT (0.42) | LMNAKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL15072062 | 0.77 | GRM4 (0.35) | LMNAKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL3377817 | 0.74 | ADORA2A (0.41) | LMNAKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL14910553 | 0.74 | LMNA (0.36) | LMNAKMT2AKDM4EALDH1A1RXFP1 | |
| SCHEMBL24921598 | 0.74 | KDM4E (0.38) | KMT2AKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL10161002 | 0.74 | MAPT (0.36) | LMNAKMT2AKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035065-A1 | PYRAZOLE DERIVATIVE AS RET INHIBITOR | 南京明德新药研发有限公司 | 2020-02-20 | — | — | WO | disclosed |