SCHEMBL2174585

SCHEMBL2174585

c1ccc2oc(-c3ccc4cc(-c5nc6ccccc6o5)ccc4c3)nc2c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 11/20 0.66
RAB9A P51151 9/20 0.66
MEN1 O00255 4/20 0.66
KMT2A Q03164 4/20 0.66
ATM Q13315 1/20 0.66
ALDH1A1 P00352 10/20 0.60
HPGD P15428 9/20 0.60
KDM4E B2RXH2 8/20 0.60
SMN1; SMN2 Q16637 7/20 0.60
TP53 P04637 5/20 0.60
HSD17B10 Q99714 6/20 0.60
ESR1 P03372 2/20 0.60
ESR2 Q92731 2/20 0.60
MAPT P10636 5/20 0.59
HCRTR1 O43613 3/20 0.59
NFKB1 P19838 2/20 0.59
STAT1 P42224 2/20 0.59
NFKB2 Q00653 2/20 0.59
RELA Q04206 2/20 0.59
GAA P10253 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19846146 0.98 NPC1 (0.64) NPC1RAB9AMEN1KMT2AATM
SCHEMBL1913541 0.96 NPC1 (0.62) NPC1RAB9AMEN1KMT2AATM
SCHEMBL30727501 0.96 NPC1 (0.62) NPC1RAB9AMEN1KMT2AATM
SCHEMBL2220920 0.95 NPC1 (0.60) NPC1RAB9AMEN1KMT2AATM
SCHEMBL19846117 0.95 NPC1 (0.60) NPC1RAB9AMEN1KMT2AATM
SCHEMBL2633271 0.94 NPC1 (0.64) NPC1RAB9AMEN1KMT2AATM
SCHEMBL17691814 0.91 NPC1 (0.60) NPC1RAB9AMEN1KMT2AATM
SCHEMBL4304890 0.90 ESR1 (0.77) NPC1RAB9AMEN1KMT2AATM
SCHEMBL19846155 0.90 KDM4E (0.57) NPC1RAB9AMEN1KMT2AATM
SCHEMBL26185759 0.90 NPC1 (0.73) NPC1RAB9AMEN1KMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9318705-B2 Organic light emitting device with roughening layer and method of producing NOVALED GMBH (DE) 2016-04-19 US disclosed
US-9318705-B2 Organic light emitting device with roughening layer and method of producing NOVALED GMBH (DE) 2016-04-19 US disclosed
EP-2267067-B1 Ultraviolet absorber composition and resin composition stabilized with the absorber composition FUJIFILM CORP (JP) 2015-08-12 EP disclosed
US-20140332794-A1 Organic Light Emitting Device and Method of Producing NOVALED GMBH (DE) 2014-11-13 US disclosed
US-20140332794-A1 Organic Light Emitting Device and Method of Producing NOVALED GMBH (DE) 2014-11-13 US disclosed
US-8044123-B2 Ultraviolet absorber composition and resin composition FUJIFILM CORPORATION (JP) 2011-10-25 US disclosed
US-7973168-B2 Metallic compound and organic electroluminescence device comprising the same SAMSUNG ELECTRONICS CO., LTD. (KR) 2011-07-05 US disclosed
EP-2267067-A1 Ultraviolet absorber composition and resin composition stabilized with the absorber composition Fujifilm Corporation (JP) 2010-12-29 EP disclosed
US-20100324181-A1 ULTRAVIOLET ABSORBER COMPOSITION AND RESIN COMPOSITION FUJIFILM CORPORATION (JP) 2010-12-23 US disclosed
US-20090326236-A1 METALLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE SAME SAMSUNG ELECTRONICS CO., LTD., (KR) 2009-12-31 US disclosed
WO-2007078183-A1 METALLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE SAME INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, HANYANG UNIVERSITY (KR) 2007-07-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090326236-A1 METALLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE SAME MT-CO1, ROS1, MAL2 NPC1 3658/4885RAB9A 579/4885MEN1 62/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.