Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747242 | 0.96 | HPGD (0.43) | HPGDTP53ALDH1A1HSD11B1POLB | |
| SCHEMBL21747296 | 0.96 | HPGD (0.39) | HPGDTP53ALDH1A1HSD11B1POLB | |
| SCHEMBL902902 | 0.72 | — | — | |
| SCHEMBL13729122 | 0.70 | KMT2A (0.30) | KMT2A | |
| SCHEMBL21747400 | 0.69 | LMNA (0.33) | HPGDTP53ALDH1A1POLBKMT2A | |
| SCHEMBL21747409 | 0.68 | CES2 (0.34) | HPGDTP53ALDH1A1HSD11B1POLB | |
| SCHEMBL21980183 | 0.68 | LMNA (0.33) | HPGDTP53ALDH1A1POLBKMT2A | |
| SCHEMBL5880920 | 0.67 | HPGD (0.50) | HPGDTP53ALDH1A1HSD11B1MEN1 | |
| SCHEMBL28524702 | 0.67 | CES2 (0.38) | HPGDTP53ALDH1A1HSD11B1POLB | |
| SCHEMBL27949317 | 0.66 | HPGD (0.54) | HPGDTP53ALDH1A1HSD11B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613742-B1 | INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE | KIND PHARMACEUTICAL (CN) | 2022-12-07 | — | — | EP | disclosed |
| CN-113004271-A | Indolizine derivative and application thereof in medicine | 杭州安道药业有限公司 | 2021-06-22 | — | — | CN | disclosed |
| CN-108484598-B | Indolizine derivative and application thereof in medicine | 杭州安道药业有限公司 | 2021-03-02 | — | — | CN | disclosed |
| EP-3613742-A1 | INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE | Kind Pharmaceutical (CN) | 2020-02-26 | — | — | EP | disclosed |