Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747442 | 0.88 | SIRT1 (0.52) | SIRT1ACKR3CHRM2ADRA2ACHRM1 | |
| SCHEMBL21747477 | 0.88 | SIRT1 (0.51) | SIRT1ACKR3CHRM2ADRA2ACHRM1 | |
| SCHEMBL21747487 | 0.87 | PDCD1 (0.47) | ACKR3PDCD1CD274HDAC6KDM4E | |
| SCHEMBL30468245 | 0.87 | SIRT1 (0.64) | SIRT1ACKR3CHRM2ADRA2ACHRM1 | |
| SCHEMBL30468251 | 0.85 | HDAC6 (0.47) | SIRT1ACKR3PDCD1CD274HDAC6 | |
| SCHEMBL21747460 | 0.85 | HDAC6 (0.47) | SIRT1ACKR3PDCD1CD274HDAC6 | |
| Trifluoroacetic Acid SCHEMBL21747462 | 0.82 | SIRT1 (0.59) | SIRT1ACKR3CHRM2ADRA2ACHRM1 | |
| SCHEMBL21747456 | 0.81 | HSD17B10 (0.54) | SIRT1KDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL21747491 | 0.77 | NPC1 (0.49) | PDCD1CD274HDAC6KDM4EALDH1A1 | |
| SCHEMBL21747471 | 0.75 | HDAC1 (0.50) | PDCD1CD274HDAC6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613735-B1 | NOVEL SIRT 1 ACTIVATOR AND MEDICINAL USE THEREOF | NAT UNIV PUSAN IND UNIV COOP FOUND (KR) | 2023-04-12 | — | — | EP | claimed |
| EP-3613735-A1 | NOVEL SIRT 1 ACTIVATOR AND MEDICINAL USE THEREOF | Pusan National University Industry - University Cooperation Foundation (KR) | 2020-02-26 | — | — | EP | claimed |
| EP-3613735-B1 | NOVEL SIRT 1 ACTIVATOR AND MEDICINAL USE THEREOF | NAT UNIV PUSAN IND UNIV COOP FOUND (KR) | 2023-04-12 | — | — | EP | disclosed |
| EP-3613735-A1 | NOVEL SIRT 1 ACTIVATOR AND MEDICINAL USE THEREOF | Pusan National University Industry - University Cooperation Foundation (KR) | 2020-02-26 | — | — | EP | disclosed |