Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 7/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747442 | 0.91 | SIRT1 (0.52) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL30468245 | 0.89 | SIRT1 (0.64) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL21747481 | 0.88 | SIRT1 (0.49) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL21747469 | 0.87 | HSD17B10 (0.48) | S1PR1S1PR3HSD17B10BCHEHDAC6 | |
| Trifluoroacetic Acid SCHEMBL21747462 | 0.86 | SIRT1 (0.59) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL21747446 | 0.84 | TP53 (0.49) | FAAHS1PR1S1PR3HSD17B10BCHE | |
| SCHEMBL21747494 | 0.80 | HSD17B10 (0.57) | SIRT1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL21747471 | 0.79 | HDAC1 (0.50) | S1PR1S1PR3HSD17B10HDAC6KDM4E | |
| SCHEMBL21747444 | 0.78 | S1PR1 (0.50) | S1PR1S1PR3HDAC6NPC1RAB9A | |
| SCHEMBL21747493 | 0.77 | SIRT1 (0.51) | SIRT1S1PR1S1PR3HSD17B10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613735-A1 | NOVEL SIRT 1 ACTIVATOR AND MEDICINAL USE THEREOF | Pusan National University Industry - University Cooperation Foundation (KR) | 2020-02-26 | — | — | EP | disclosed |