Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21747995 | 0.91 | FGFR4 (0.49) | FGFR4JAK3MAPKAPK2ALKEGFR | |
| SCHEMBL21753048 | 0.88 | EGFR (0.40) | PDE3BPDE3AFGFR4JAK3MAPT | |
| SCHEMBL29700774 | 0.88 | EGFR (0.40) | PDE3BPDE3AFGFR4JAK3MAPT | |
| SCHEMBL21747965 | 0.85 | ALK (0.37) | FGFR4JAK3ALK | |
| SCHEMBL21747950 | 0.83 | BTK (0.38) | FGFR4MAPTALK | |
| SCHEMBL24699679 | 0.81 | FGFR4 (0.50) | FGFR4JAK3MAPKAPK2ALKEGFR | |
| SCHEMBL21747911 | 0.79 | FGFR4 (0.48) | FGFR4JAK3MAPKAPK2ALKEGFR | |
| SCHEMBL21761373 | 0.78 | EGFR (0.41) | PDE3BPDE3AFGFR4JAK3MAPT | |
| SCHEMBL21761299 | 0.77 | FGFR4 (0.46) | FGFR4JAK3MAPKAPK2ALKEGFR | |
| SCHEMBL21760533 | 0.77 | EGFR (0.40) | PDE3BPDE3AFGFR4JAK3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613738-A1 | 4-SUBSTITUTED PYRROLO[2,3-B]PYRIDINE AS ERBB MODULATORS USEFUL FOR TREATING CANCER | Lead Discovery Center GmbH (DE) | 2020-02-26 | — | — | EP | disclosed |