Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 7/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21748138 | 0.73 | APLNR (0.52) | APLNR | |
| SCHEMBL21328103 | 0.72 | APLNR (0.47) | APLNR | |
| SCHEMBL21328182 | 0.72 | APLNR (0.47) | APLNR | |
| SCHEMBL21328106 | 0.72 | APLNR (0.47) | APLNR | |
| SCHEMBL21328105 | 0.72 | APLNR (0.47) | APLNR | |
| SCHEMBL21328300 | 0.72 | APLNR (0.47) | APLNR | |
| SCHEMBL21328246 | 0.72 | APLNR (0.47) | APLNR | |
| SCHEMBL21328183 | 0.72 | APLNR (0.47) | APLNR | |
| SCHEMBL20188595 | 0.72 | APLNR (0.44) | APLNRCA1CA2CA9POLB | |
| SCHEMBL20188593 | 0.72 | APLNR (0.44) | APLNRCA1CA2CA9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3300500-B9 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3300500-B1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-02-26 | — | — | EP | disclosed |