Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.52 |
| ▸ | TET3 | O43151 | 2/20 | 0.52 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL711844 | 0.97 | SMN1; SMN2 (0.88) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL31673489 | 0.97 | — | — | |
| Malic Acid SCHEMBL89131 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL29410671 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL98496 | 0.97 | — | — | |
| Malic Acid SCHEMBL31673494 | 0.97 | — | — | |
| Malic Acid SCHEMBL256122 | 0.97 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 | |
| Malic Acid SCHEMBL856 | 0.97 | — | — | |
| Malic Acid SCHEMBL28355917 | 0.97 | SMN1; SMN2 (1.00) | SMN1; SMN2SLC22A6TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 885 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11649709-B2 | Polymer blends for stimulation of oil and gas wells | Energy Solutions (US) LLC (US) | 2023-05-16 | — | — | US | claimed |
| US-20220348820-A1 | CROSSLINKED PROPPANT-GEL MATRIX | HEXION INC. | 2022-11-03 | — | — | US | claimed |
| US-11459885-B2 | Workflow for predictive model to select formation damage treatment | HALLIBURTON ENERGY SERVICES, INC. (US) | 2022-10-04 | — | — | US | claimed |
| US-11447689-B2 | Crosslinked proppant-gel matrix | HEXION INC. (US) | 2022-09-20 | — | — | US | claimed |
| CN-109863221-B | Polymer blends for stimulation of oil and gas wells | 罗地亚经营管理公司 | 2021-12-24 | — | — | CN | claimed |
| US-20210207464-A1 | POLYMER BLENDS FOR STIMULATION OF OIL & GAS WELLS | RHODIA OPERATIONS (FR) | 2021-07-08 | — | — | US | claimed |
| US-10982519-B2 | Polymer blends for stimulation of oil and gas wells | RHODIA OPERATIONS (FR) | 2021-04-20 | — | — | US | claimed |
| US-20210095186-A1 | CROSSLINKED PROPPANT-GEL MATRIX | HEXION INC. | 2021-04-01 | — | — | US | claimed |
| US-10883041-B2 | Crosslinked proppant-gel matrix | HEXION INC. (US) | 2021-01-05 | — | — | US | claimed |
| EP-3512918-A1 | POLYMER BLENDS FOR STIMULATION OF OIL&GAS WELLS | Rhodia Operations (FR) | 2019-07-24 | — | — | EP | claimed |
| US-7297665-B2 | Fluids comprising zirconium isopropylamine crosslinking agents and associated methods | HALLIBURTON ENERGY SERVICES, INC. (US) | 2007-11-20 | — | — | US | claimed |
| US-7225874-B2 | Methods and compositions for reducing the viscosity of treatment fluids used in subterranean operations | HALLIBURTON ENERGY SERVICES, INC. (US) | 2007-06-05 | — | — | US | claimed |
| US-7205264-B2 | Well treatment method using fluid containing lactic acid or salt thereof | BJ SERVICES COMPANY (US) | 2007-04-17 | — | — | US | claimed |
| WO-2007020390-A1 | METHODS AND COMPOSITIONS FOR REDUCING THE VISCOSITY OF TREATMENT FLUIDS USED IN SUBTERRANEAN OPERATIONS | HALLIBURTON ENERGY SERVICES, INC. (US) | 2007-02-22 | — | — | WO | claimed |
| US-20070034376-A1 | Providing a treatment fluid that comprises an aqueous base fluid and a gelling agent; providing a breaker that comprises a hydroquinone component; allowing the breaker to interact with the treatment fluid; and allowing the breaker to at least partially reduce the viscosity of the treatment fluid | HALLIBURTON ENERGY SERVICES, INC. | 2007-02-15 | — | — | US | claimed |
| US-20070037713-A1 | Comprises a gelling agent, the breaker comprising a hydroquinone component and an additional breaker component | HALLIBURTON ENERGY SERVICES, INC. | 2007-02-15 | — | — | US | claimed |
| WO-2006117517-A2 | ACIDIC TREATMENT FLUIDS COMPRISING SCLEROGLUCAN AND/OR DIUTAN AND ASSOCIATED METHODS | HALLIBURTON ENERGY SERVICES, INC. (US) | 2006-11-09 | — | — | WO | claimed |
| US-20060247135-A1 | Acidic treatment fluids comprising scleroglucan and/or diutan and associated methods | HALLIBURTON ENERGY SERVICES, INC. | 2006-11-02 | — | — | US | claimed |
| US-20060229213-A1 | Fluids comprising zirconium isopropylamine crosslinking agents and associated methods | HALLIBURTON ENERGY SERVICES, INC. | 2006-10-12 | — | — | US | claimed |
| US-20040152602-A1 | Crosslinking delaying agents for acid fluids | BAKER HUGHES HOLDINGS LLC | 2004-08-05 | — | — | US | claimed |