Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GZMB | P10144 | 12/20 | 0.42 |
| ▸ | XIAP | P98170 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17491007 | 1.00 | GZMB (0.42) | GZMBXIAPAKT1MC4RMC3R | |
| SCHEMBL19182566 | 1.00 | GZMB (0.42) | GZMBXIAPAKT1MC4RMC3R | |
| SCHEMBL19181276 | 1.00 | GZMB (0.42) | GZMBXIAPAKT1MC4RMC3R | |
| SCHEMBL17491013 | 0.94 | GZMB (0.44) | GZMBXIAP | |
| SCHEMBL20845516 | 0.94 | GZMB (0.41) | GZMBXIAPFFAR2MME | |
| SCHEMBL19182564 | 0.94 | GZMB (0.44) | GZMBXIAP | |
| SCHEMBL21750850 | 0.94 | GZMB (0.44) | GZMBXIAP | |
| SCHEMBL17490987 | 0.94 | GZMB (0.41) | GZMBXIAPFFAR2MME | |
| SCHEMBL19181272 | 0.94 | GZMB (0.44) | GZMBXIAP | |
| SCHEMBL19181281 | 0.94 | GZMB (0.41) | GZMBXIAPFFAR2MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062803-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062803-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | GZMB, DNASE1L3, DNASE1 | GZMB 1/4885XIAP 137/4885AKT1 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.