SCHEMBL21751247

SCHEMBL21751247

FC(F)(F)Oc1cccc(CSc2ncc(Cl)s2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.41
POLB P06746 1/20 0.39
KCNN4 O15554 3/20 0.39
EPHX1 P07099 1/20 0.39
KCNN3 Q9UGI6 1/20 0.38
GLS O94925 1/20 0.38
TERT O14746 1/20 0.38
CETP P11597 1/20 0.38
NPC1 O15118 1/20 0.37
LMNA P02545 1/20 0.37
RAB9A P51151 1/20 0.37
SCD O00767 1/20 0.37
CNR1 P21554 1/20 0.37
DAO P14920 1/20 0.37
CHRM2 P08172 1/20 0.37
CHRM1 P11229 1/20 0.37
CHRM3 P20309 1/20 0.37
KDM5A P29375 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
KDM5B Q9UGL1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21751245 0.79 CTSA (0.46) PTPN1POLBKCNN4EPHX1CETP
SCHEMBL27174936 0.75 HSD17B10 (0.46) POLBNPC1LMNARAB9A
SCHEMBL21751243 0.74 TRPM8 (0.40) KCNN4KCNN3CETPCNR1DAO
SCHEMBL4217539 0.71 ALDH1A1 (0.49) POLBNPC1LMNA
SCHEMBL5526398 0.70 EPHX1 (0.48) EPHX1CETPCNR1DAOCHRM2
SCHEMBL5526402 0.70 CHRM2 (0.50) EPHX1CETPDAOCHRM2CHRM1
SCHEMBL5367845 0.69 EPHX1 (0.46) EPHX1CETPNPC1RAB9ADAO
SCHEMBL31634206 0.67 CETP (0.51) KCNN3CETPCNR1DAOCHRM2
SCHEMBL1434302 0.67 CETP (0.51) KCNN3CETPCNR1DAOCHRM2
SCHEMBL5009648 0.67 DAO (0.55) CETPCNR1DAOCHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200060276-A1 THIAZOLE COMPOUND AND HERBICIDE OAT AGRIO CO., LTD. (JP) 2020-02-27 US disclosed
US-20200060276-A1 THIAZOLE COMPOUND AND HERBICIDE OAT AGRIO CO., LTD. (JP) 2020-02-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200060276-A1 THIAZOLE COMPOUND AND HERBICIDE OR10J3, OXSR1, OXER1 PTPN1 1042/4885POLB 4571/4885KCNN4 591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.