Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM1A | O60341 | 4/20 | 0.53 |
| ▸ | MAOA | P21397 | 3/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175244 | 0.79 | POLB (0.53) | TP53MAPTKDM1AMAOAMAOB | |
| SCHEMBL26135641 | 0.76 | AKR1C1 (0.44) | — | |
| Benzyl Phenylcarbamate SCHEMBL1222943 | 0.75 | POLB (0.78) | TP53MAPTKDM1AMAOAMAOB | |
| SCHEMBL6607260 | 0.75 | NPC1 (0.55) | TP53MAPTKDM1AMAOAMAOB | |
| SCHEMBL15777029 | 0.74 | TP53 (0.67) | TP53MAPTKDM1AMAOAMAOB | |
| SCHEMBL3803479 | 0.74 | L3MBTL1 (0.47) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL7663567 | 0.74 | POLB (0.68) | TP53MAPTKDM1AMAOAMAOB | |
| SCHEMBL1707562 | 0.74 | POLB (0.68) | TP53MAPTKDM1AMAOAMAOB | |
| SCHEMBL1870929 | 0.74 | POLB (0.71) | TP53MAPTKDM1AMAOAMAOB | |
| SCHEMBL6614111 | 0.74 | POLB (0.50) | TP53MAPTKDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189036-B1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS | ARQULE INC (US) | 2023-07-19 | — | — | EP | disclosed |
| CN-111494378-A | Compositions and methods for treating proliferative disorders | 艾科尔公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-107074769-B | Compositions and methods for treating proliferative disorders | 艾科尔公司 | 2020-04-07 | — | — | CN | disclosed |
| US-9949981-B2 | Compositions and methods for treating proliferation disorders | ARQULE, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| EP-3189036-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS | ArQule, Inc. (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016037044-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS | ARQULE, INC. (US) | 2016-03-10 | — | — | WO | disclosed |
| US-20160067260-A1 | Compositions and Methods for Treating Proliferation Disorders | ARQULE, INC. | 2016-03-10 | — | — | US | disclosed |
| EP-2519522-B1 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE INC (US) | 2014-09-24 | — | — | EP | disclosed |
| EP-2519522-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160067260-A1 | Compositions and Methods for Treating Proliferation Disorders | MKI67, HRAS, VHL | TP53 6/4885MAPT 3746/4885KDM1A 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.