Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 5/20 | 0.38 |
| ▸ | PPARA | Q07869 | 12/20 | 0.36 |
| ▸ | PPARD | Q03181 | 8/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL814693 | 0.86 | FBP1 (0.49) | SRCFBP1PPARAPPARDPPARG | |
| SCHEMBL21758957 | 0.81 | HPGD (0.33) | FBP1PPARAPPARDPPARGCYP3A4 | |
| SCHEMBL20702486 | 0.80 | SRC (0.46) | SRCFBP1PPARAPPARDPPARG | |
| SCHEMBL11893197 | 0.79 | SRC (0.45) | SRCFBP1PPARAPPARDPPARG | |
| SCHEMBL5480699 | 0.78 | FBP1 (0.46) | SRCFBP1PPARAPPARDPPARG | |
| SCHEMBL5479986 | 0.76 | FBP1 (0.46) | SRCFBP1PPARACYP3A4ABCB11 | |
| SCHEMBL5472116 | 0.76 | PPARA (0.53) | SRCPPARAPPARDPPARGKCNH2 | |
| SCHEMBL14290098 | 0.76 | SRC (0.43) | SRCFBP1PPARAPPARDPPARG | |
| SCHEMBL21758868 | 0.76 | PPARA (0.71) | PPARAPPARDPPARG | |
| SCHEMBL21188213 | 0.73 | FBP1 (0.48) | FBP1PPARAPPARDPPARGCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020039297-A1 | NOVEL COMPOUNDS AND THEIR USE IN PREPARATION OF ELAFIBRANOR AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF | MANKIND PHARMA LTD. (IN) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020039297-A1 | NOVEL COMPOUNDS AND THEIR USE IN PREPARATION OF ELAFIBRANOR AND PHARMACEUTICAL ACCEPTABLE SALTS THEREOF | MANKIND PHARMA LTD. (IN) | 2020-02-27 | — | — | WO | disclosed |