Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eptifibatide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 known ✓ | P05106 | 1/20 | 0.76 |
| ▸ | ITGA2B known ✓ | P08514 | 1/20 | 0.76 |
| ▸ | ITGAV | P06756 | 1/20 | 0.76 |
| ▸ | LDLR | P01130 | 16/20 | 0.57 |
| ▸ | PCSK9 | Q8NBP7 | 16/20 | 0.57 |
| ▸ | TSLP | Q969D9 | 2/20 | 0.51 |
| ▸ | NECTIN4 | Q96NY8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eptifibatide SCHEMBL21753462 | 0.96 | ITGB3 (0.81) | ITGB3ITGAVITGA2BLDLRPCSK9 | |
| Eptifibatide SCHEMBL29398425 | 0.96 | ITGB3 (0.82) | ITGB3ITGAVITGA2BLDLRPCSK9 | |
| Eptifibatide SCHEMBL15781 | 0.96 | ITGB3 (0.82) | ITGB3ITGAVITGA2BLDLRPCSK9 | |
| Eptifibatide SCHEMBL571287 | 0.96 | ITGB3 (0.82) | ITGB3ITGAVITGA2BLDLRPCSK9 | |
| Eptifibatide SCHEMBL8284422 | 0.96 | ITGB3 (0.82) | ITGB3ITGAVITGA2BLDLRPCSK9 | |
| Eptifibatide SCHEMBL7107217 | 0.95 | ITGB3 (0.81) | ITGB3ITGAVITGA2BLDLRPCSK9 | |
| Eptifibatide SCHEMBL1890434 | 0.94 | ITGB3 (0.80) | ITGB3ITGAVITGA2BLDLRPCSK9 | |
| SCHEMBL24433365 | 0.94 | ITGB3 (0.81) | ITGB3ITGAVITGA2BLDLRPCSK9 | |
| SCHEMBL22193885 | 0.94 | ITGB3 (0.81) | ITGB3ITGAVITGA2BLDLRPCSK9 | |
| Eptifibatide SCHEMBL2830072 | 0.93 | ITGB3 (0.78) | ITGB3ITGAVITGA2BLDLRPCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037729-A1 | METHOD FOR SYNTHESIZING INTEGRILIN THIOETHER | 深圳翰宇药业股份有限公司 | 2020-02-27 | — | — | WO | disclosed |