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Eptifibatide

Eptifibatide

SCHEMBL571287

N=C(N)NCCCC[C@@H]1NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)CNC1=O.N=C(N)NCCCC[C@@H]1NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)CNC1=O

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ITGA2BITGB3

The experimentally established mechanism targets of Eptifibatide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ ITGB3 known ✓ P05106 1/20 0.82
▸ ITGA2B known ✓ P08514 1/20 0.82
▸ ITGAV P06756 1/20 0.82
▸ LDLR P01130 8/20 0.56
▸ PCSK9 Q8NBP7 8/20 0.56
▸ TSLP Q969D9 9/20 0.54
▸ MC4R P32245 1/20 0.53
▸ MC5R P33032 1/20 0.53
▸ MC3R P41968 1/20 0.53
▸ MC1R Q01726 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eptifibatide SCHEMBL15781 1.00 ITGB3 (0.82) ITGB3ITGAVITGA2BLDLRPCSK9
Eptifibatide SCHEMBL8284422 1.00 ITGB3 (0.82) ITGB3ITGAVITGA2BLDLRPCSK9
Eptifibatide SCHEMBL29398425 1.00 ITGB3 (0.82) ITGB3ITGAVITGA2BLDLRPCSK9
Eptifibatide SCHEMBL7107217 0.99 ITGB3 (0.81) ITGB3ITGAVITGA2BLDLRPCSK9
Eptifibatide SCHEMBL21753462 0.99 ITGB3 (0.81) ITGB3ITGAVITGA2BLDLRPCSK9
Eptifibatide SCHEMBL1890434 0.98 ITGB3 (0.80) ITGB3ITGAVITGA2BLDLRPCSK9
SCHEMBL24433365 0.98 ITGB3 (0.81) ITGB3ITGAVITGA2BLDLRPCSK9
SCHEMBL22193885 0.98 ITGB3 (0.81) ITGB3ITGAVITGA2BLDLRPCSK9
Eptifibatide SCHEMBL2830072 0.97 ITGB3 (0.78) ITGB3ITGAVITGA2BLDLRPCSK9
Eptifibatide SCHEMBL21753468 0.96 ITGB3 (0.76) ITGB3ITGAVITGA2BLDLRPCSK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3676363-A1 PERFUSION APPARATUS FOR USE IN BIOREACTOR SYSTEMS Lonza Ltd (CH) 2020-07-08 — — EP disclosed
EP-3464547-A1 SINGLE USE BIOREACTOR Lonza Limited (CH) 2019-04-10 — — EP disclosed
WO-2019067966-A1 PERFUSION APPARATUS FOR USE IN BIOREACTOR SYSTEMS LONZA LTD. (CH) 2019-04-04 — — WO disclosed
EP-3423588-A1 IMPROVED FERMENTATION PROCESS Lonza Ltd (CH) 2019-01-09 — — EP disclosed
WO-2017207822-A1 SINGLE USE BIOREACTOR LONZA LIMITED (CH) 2017-12-07 — — WO disclosed
WO-2013116061-A1 INSERTION AND REMOVAL METHODS AND APPARATUS FOR THERAPEUTIC DEVICES FORSIGHT VISION4, INC. (US) 2013-08-08 — — WO disclosed
EP-2600812-A2 IMPLANTABLE THERAPEUTIC DEVICE Forsight Vision4, Inc. (US) 2013-06-12 — — EP disclosed
EP-2555801-A1 SELECTION AND USE OF HOST CELLS FOR PRODUCTION OF GLYCOPROTEINS Momenta Pharmaceuticals, Inc. (US) 2013-02-13 — — EP disclosed
WO-2012019176-A2 IMPLANTABLE THERAPEUTIC DEVICE FORSIGHT VISION4 INC. (US) 2012-02-09 — — WO disclosed
WO-2011127325-A1 SELECTION AND USE OF HOST CELLS FOR PRODUCTION OF GLYCOPROTEINS MOMENTA PHARMACEUTICALS, INC. (US) 2011-10-13 — — WO disclosed