Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126817 | 0.78 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4464289 | 0.77 | CA12 (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL31114418 | 0.76 | GABRA1 (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1126787 | 0.76 | NOTUM (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4483520 | 0.75 | PPARG (0.53) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1990531 | 0.73 | JAK2 (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL12393146 | 0.72 | AR (0.55) | NPC1RAB9AMAPTMEN1GAA | |
| SCHEMBL19995990 | 0.72 | GABRP (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4485385 | 0.71 | KDR (0.52) | KDR | |
| SCHEMBL14800310 | 0.70 | GABRP (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020038405-A1 | PREPARATION METHOD OF PYRROLO-AMINO-PYRIDAZINONE COMPOUND AND INTERMEDIATE THEREOF | 江苏恒瑞医药股份有限公司 | 2020-02-27 | — | — | WO | disclosed |