Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29382375 | 0.94 | MKNK1 (0.55) | KCNA5MKNK1MKNK2KCNH2PTGS2 | |
| SCHEMBL3735688 | 0.85 | KCNA5 (0.59) | KCNA5MKNK1MKNK2KCNH2PTGS2 | |
| SCHEMBL1547038 | 0.83 | KMT2A (0.56) | ATRKMT2A | |
| Hydrochloric Acid SCHEMBL27396597 | 0.81 | KMT2A (0.55) | ATRKMT2A | |
| SCHEMBL2555729 | 0.80 | KCNA5 (0.51) | KCNA5MKNK1MKNK2KCNH2PTGS2 | |
| SCHEMBL3288789 | 0.80 | DPP4 (0.62) | KCNA5KCNH2PTGS2CYP2A6ALDH1A1 | |
| SCHEMBL9285273 | 0.80 | KCNA5 (0.59) | KCNA5KCNH2PTGS2CYP2A6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2456280 | 0.78 | DPP4 (0.60) | KCNA5KCNH2PTGS2CYP2A6ALDH1A1 | |
| SCHEMBL27343138 | 0.78 | KCNA5 (0.48) | KCNA5MKNK1MKNK2KCNH2PTGS2 | |
| SCHEMBL7311559 | 0.78 | BCAT2 (0.50) | ATRALDH1A1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973047-B2 | Beta-Secretase modulators and methods of use | AMGEN INC. (US) | 2011-07-05 | — | — | US | disclosed |
| US-20100222338-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222338-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, BACE2, APP | KCNA5 2590/4885MKNK1 1868/4885MKNK2 2039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.