Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | SIRT6 | Q8N6T7 | 10/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 5/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL975415 | 0.90 | MAPT (0.59) | MAPTMAPK1L3MBTL1NPSR1ALDH1A1 | |
| SCHEMBL16262967 | 0.88 | MAPT (0.51) | MAPTSIRT6NPSR1ALDH1A1KDM4E | |
| SCHEMBL16262970 | 0.88 | MAPT (0.51) | MAPTSIRT6NPSR1ALDH1A1KDM4E | |
| SCHEMBL5457891 | 0.86 | MAPT (0.64) | MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL19633486 | 0.85 | KMT2A (0.50) | MAPTSIRT6MAPK1NPSR1ALDH1A1 | |
| SCHEMBL19633305 | 0.82 | MAPT (0.54) | MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL16270618 | 0.82 | MAPT (0.61) | MAPTSIRT6NPSR1ALDH1A1KDM4E | |
| SCHEMBL5332939 | 0.81 | ALDH1A1 (0.48) | MAPTSIRT6MAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL19633404 | 0.81 | MAPT (0.53) | MAPTMAPK1NPSR1ALDH1A1 | |
| SCHEMBL14669416 | 0.81 | ALDH1A1 (0.48) | MAPTSIRT6MAPK1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110857300-B | Condensed ring triazole compounds, preparation method and application | 上海凌达生物医药有限公司 | 2021-11-05 | — | — | CN | disclosed |
| CN-109721600-B | Nitrogen-containing fused ring compounds and preparation method and application thereof | 上海凌达生物医药有限公司 | 2021-04-27 | — | — | CN | disclosed |
| CN-110857300-A | Condensed ring triazole compounds, preparation method and application | 如东凌达生物医药科技有限公司 | 2020-03-03 | — | — | CN | disclosed |
| WO-2020038458-A1 | CLASS OF FUSED RING TRIAZOLE COMPOUND, PREPARATION METHOD, AND USE | 如东凌达生物医药科技有限公司 | 2020-02-27 | — | — | WO | disclosed |