Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30346659 | 1.00 | TDP1 (0.31) | TDP1USP2ALDH1A1CYP3A4MAPT | |
| SCHEMBL30346501 | 1.00 | TDP1 (0.31) | TDP1USP2ALDH1A1CYP3A4MAPT | |
| SCHEMBL30346502 | 1.00 | TDP1 (0.31) | TDP1USP2ALDH1A1CYP3A4MAPT | |
| SCHEMBL28914556 | 0.84 | TDP1 (0.31) | TDP1USP2ALDH1A1CYP3A4MAPT | |
| SCHEMBL30151172 | 0.84 | TDP1 (0.31) | TDP1USP2ALDH1A1CYP3A4MAPT | |
| SCHEMBL8829437 | 0.84 | TDP1 (0.31) | TDP1USP2ALDH1A1CYP3A4MAPT | |
| SCHEMBL31707312 | 0.82 | — | — | |
| SCHEMBL9141103 | 0.82 | — | — | |
| SCHEMBL1491885 | 0.76 | — | — | |
| SCHEMBL16267436 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11692004-B2 | Substituted pyrazole compound, preparation method therefor, pharmaceutical composition and medical use thereof | JIANGSU VANGUARD PHARMACEUTICAL CO., LTD. (CN) | 2023-07-04 | — | — | US | disclosed |
| CN-110218231-B | Cyclobutane dicarboxylic acid platinum complex, intermediate thereof, preparation method thereof, pharmaceutical composition and application thereof | 天津谷堆生物医药科技有限公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-110857285-B | Substituted pyrazole compound, preparation method, pharmaceutical composition and application thereof | 江苏万高药业股份有限公司 | 2022-12-20 | — | — | CN | disclosed |
| US-20220372058-A1 | Substituted Pyrazole Compound, Preparation Method Therefor, Pharmaceutical Composition and Medical Use Thereof | JIANGSU VANGUARD PHARMACEUTICAL CO., LTD (CN) | 2022-11-24 | — | — | US | disclosed |
| CN-113004350-A | Mannose-modified azide exosome and application thereof | 中国科学院重庆绿色智能技术研究院 | 2021-06-22 | — | — | CN | disclosed |
| CN-110857285-A | Substituted pyrazole compound, preparation method, pharmaceutical composition and application thereof | 天津谷堆生物医药科技有限公司 | 2020-03-03 | — | — | CN | disclosed |
| WO-2020038279-A1 | SUBSTITUTED PYRAZOLE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF | 天津谷堆生物医药科技有限公司 | 2020-02-27 | — | — | WO | disclosed |
| CN-110218231-A | Cyclobutane dicarboxylic acid platinum complex, wherein mesosome, preparation method, pharmaceutical composition and purposes | 天津谷堆生物医药科技有限公司 | 2019-09-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220372058-A1 | Substituted Pyrazole Compound, Preparation Method Therefor, Pharmaceutical Composition and Medical Use Thereof | FARS2, GOT2, HADHB | TDP1 564/4885USP2 4228/4885ALDH1A1 2197/4885 |
| US-11692004-B2 | Substituted pyrazole compound, preparation method therefor, pharmaceutical composition and medical use thereof | FARS2, GOT2, HADHB | TDP1 564/4885USP2 4228/4885ALDH1A1 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.