Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 6/20 | 0.49 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.49 |
| ▸ | BRD4 | O60885 | 10/20 | 0.48 |
| ▸ | TAF1 | P21675 | 2/20 | 0.48 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 8/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | NEK4 | P51957 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21755686 | 0.89 | BRD4 (0.64) | PLK1TTKPLK3PLK2BRD4 | |
| SCHEMBL21755701 | 0.85 | PLK1 (0.66) | PLK1TTKPLK3PLK2BRD4 | |
| SCHEMBL10098794 | 0.82 | PLK1 (0.69) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL619956 | 0.82 | PLK1 (0.69) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL2398350 | 0.78 | PLK1 (0.54) | PLK1TTKPLK3PLK2BRD4 | |
| SCHEMBL2394118 | 0.76 | PLK1 (0.68) | PLK1TTKPLK3PLK2BRD4 | |
| SCHEMBL2394142 | 0.76 | PLK1 (0.68) | PLK1TTKPLK3PLK2BRD4 | |
| SCHEMBL4104990 | 0.76 | PLK1 (0.70) | PLK1TTKPLK3PLK2BRD4 | |
| SCHEMBL21755692 | 0.76 | PLK1 (0.68) | PLK1TTKPLK3PLK2BRD4 | |
| SCHEMBL3987399 | 0.75 | PLK1 (0.74) | PLK1TTKPLK3BRD4TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570154-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570154-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders | BRSK2, STK3, BRSK1 | PLK1 110/4885TTK 41/4885PLK3 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.