Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15132087 | 0.82 | ALDH1A1 (0.43) | KDM4EMAPTGAAERN1ALDH1A1 | |
| SCHEMBL15065880 | 0.81 | DRD2 (0.41) | KDM4EMAPTGAAERN1ALDH1A1 | |
| SCHEMBL30078089 | 0.81 | DRD2 (0.41) | KDM4EMAPTGAAERN1ALDH1A1 | |
| SCHEMBL15065075 | 0.78 | ALDH1A1 (0.36) | KDM4EMAPTERN1ALDH1A1LMNA | |
| SCHEMBL30078102 | 0.75 | GRM5 (0.37) | KDM4EMAPTGAAERN1ALDH1A1 | |
| SCHEMBL15065596 | 0.75 | GRM5 (0.37) | KDM4EMAPTGAAERN1ALDH1A1 | |
| SCHEMBL30078196 | 0.71 | MAPT (0.38) | KDM4EMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL15065234 | 0.71 | MAPT (0.38) | KDM4EMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL21748406 | 0.70 | DHODH (0.39) | KDM4EMAPTERN1ALDH1A1LMNA | |
| SCHEMBL15065726 | 0.70 | HSD17B10 (0.38) | KDM4EMAPTALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797597-B1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS INC (US) | 2020-02-26 | — | — | EP | disclosed |